Lin, Bingpeng and Ser, Hooi Leng and Wang, Lijing and Li, Jiang and Chan, Kok-Gan and Lee, Learn-Han and Tan, Loh Teng-Hern (2023) The emerging role of MMP12 in the oral environment. International Journal of Molecular Sciences, 24 (5). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms24054648.
Full text not available from this repository.Abstract
Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya, RMF1252-2021, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, ECR-000039 |
| Uncontrolled Keywords: | MMP12; Tissue expression; Periodontitis; Bone remodelling; OTM; OSCC |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Nov 2023 07:14 |
| Last Modified: | 27 Nov 2023 07:14 |
| URI: | http://eprints.um.edu.my/id/eprint/38526 |
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