Chew, Ching Hoong and Yeo, Chew Chieng and Hamzah, Ainal Mardziah Che and Al-Trad, Esra'a I. and Jones, Sherry Usun and Chua, Kek Heng and Puah, Suat Moi (2023) Multidrug-resistant methicillin-resistant staphylococcus aureus associated with hospitalized newborn infants. Diagnostics, 13 (6). ISSN 2075-4418, DOI https://doi.org/10.3390/diagnostics13061050.
Full text not available from this repository.Abstract
Multidrug resistance (MDR) is a significant challenge in healthcare management, and addressing it requires a comprehensive approach. In this study, we employed a combination of phenotypic and genotypic approaches, along with whole genome sequencing (WGS) to investigate five hospital-associated MDR methicillin-resistant Staphylococcus aureus (MRSA) strains that were isolated from newborn infants. Our analysis revealed the following for the MDR-MRSA strains: SauR31 was resistant to three antimicrobial classes; SauR12, SauR91 and SauR110 were resistant to four antimicrobial classes; and SauR23 exhibited resistance to seven classes. All the MDR-MRSA strains were capable of producing slime and biofilms, harbored SCCmec type IV, and belonged to different spa types (t022, t032, and t548), with varying profiles for microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and virulence genes. The WGS data for the MDR SauR23 and SauR91 strains revealed that most of the antimicrobial resistance gene
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antibiotic susceptibility testing; Biofilm; Methicillin-resistant staphylococcus aureus; Multidrug resistance; neonates; whole genome sequencing |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Medicine Faculty of Medicine > Biomedical Imaging Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 25 Oct 2024 03:41 |
| Last Modified: | 25 Oct 2024 03:41 |
| URI: | http://eprints.um.edu.my/id/eprint/38488 |
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