Quorum sensing in aeromonas species isolated from patients in Malaysia

Chan, K.G.; Puthucheary, S.D.; Chan, X.Y.; Yin, W.F.; Wong, C.S.; Too, W.S.S.; Chua, K.H. (2011) Quorum sensing in aeromonas species isolated from patients in Malaysia. Current microbiology, 62 (1). pp. 167-172. ISSN 0343-8651

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    Abstract

    Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pus, stool and urine). All isolates produced the two principal AHLs, N-butanoylhomoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). Ten isolates also produced additional AHLs. This report is the first documentation of Aeromonas sobria producing C6-HSL and two additional AHLs with N-acyl side chain longer than C(6). Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen.

    Item Type: Article
    Creators:
    1. Chan, K.G.
    2. Puthucheary, S.D.
    3. Chan, X.Y.
    4. Yin, W.F.
    5. Wong, C.S.
    6. Too, W.S.S.
    7. Chua, K.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: Current microbiology
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Molecular Medicine
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms azrahani halim
    Date Deposited: 01 Oct 2012 11:26
    Last Modified: 01 Oct 2012 11:26
    URI: http://eprints.um.edu.my/id/eprint/3845

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