Liau, Xiew Leng and Salvamani, Shamala and Gunasekaran, Baskaran and Chellappan, Dinesh Kumar and Rhodes, Anthony and Ulaganathan, Vaidehi and Tiong, Yee Lian (2023) CCAT 1-A pivotal oncogenic long non-coding RNA in colorectal cancer. British Journal of Biomedical Science, 80. ISSN 0967-4845, DOI https://doi.org/10.3389/bjbs.2023.11103.
Full text not available from this repository.Abstract
Colorectal cancer (CRC) is ranked as the third most common cancer and second deadliest cancer in both men and women in the world. Currently, the cure rate and 5-year survival rate of CRC patients remain relatively low. Therefore, discovering a novel molecular biomarker that can be used to improve CRC screening, diagnosis, prognosis, and treatment would be beneficial. Long non-coding RNA colon cancer-associated transcript 1 (CCAT 1) has been found overexpressed in CRC and is associated with CRC tumorigenesis and treatment outcome. CCAT 1 has a high degree of specificity and sensitivity, it is readily detected in CRC tissues and is significantly overexpressed in both premalignant and malignant CRC tissues. Besides, CCAT 1 is associated with clinical manifestation and advanced features of CRC, such as lymph node metastasis, high tumor node metastasis stage, differentiation, invasion, and distant metastasis. In addition, they can upregulate oncogenic c-MYC and negatively modulate microRNAs via different mechanisms of action. Furthermore, dysregulated CCAT 1 also enhances the chemoresistance in CRC cells while downregulation of them reverses the malignant phenotypes of cancer cells. In brief, CCAT 1 serves as a potential screening, diagnostic and prognostic biomarker in CRC, it also serves as a potential therapeutic marker to treat CRC patients.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Biomarker; Long non-coding RNA; Colorectal cancer; CCAT 1; C-MYC |
| Subjects: | R Medicine R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine > Pathology Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 05 Jul 2023 06:59 |
| Last Modified: | 05 Jul 2023 06:59 |
| URI: | http://eprints.um.edu.my/id/eprint/38416 |
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