Tan, Pei Yee and Loganathan, Radhika and Teng, Kim-Tiu and Lee, Soo Ching and Johari, Syahirah Nadiah Mohd and Selvaduray, Kanga Rani and Ngui, Romano and Lim, Yvonne Ai-Lian (2023) Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD). Acta Tropica, 240. ISSN 0001-706X, DOI https://doi.org/10.1016/j.actatropica.2023.106860.
Full text not available from this repository.Abstract
Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoolchildren (8-12 years old) with vitamin A deficiency (VAD) in rural areas of Malaysia to investigate the effects of red palm olein (RPO)-enriched biscuits on STH reinfection rates and infection intensities. The effects of the RPO-enriched biscuits (experimental group, n = 153) and palm olein (PO)-enriched biscuits (control group, n = 190), were assessed at 3-and 6-month after the administration of complete triple-dose albendazole (one dose of 400 mg for three consecutive days). The overall STH infection rate at baseline was recorded at 65.6%. At 6-month, a significantly lower reinfection rate of A. lumbricoides was observed in the experimental group (35.3%) compared to the control group (60.0%) (P< 0.05), and a significant reduction in fecal egg count (epg) of A. lumbricoides was observed in the experimental group from baseline (P< 0.001), but no significant reduction was observed in the control group. No significant differences in the reduction of infection intensities of T. trichiura and hookworm were observed between experimental and control groups at 3-and 6-month (P>0.05). These findings suggest the potential beneficial effects of RPO-enriched biscuit supplementation on the reinfection of A. lumbricoides, which could be attributed to its high carotenoids content by enhancing host immune response and mucosal epithelium integrity. However, further studies are warranted to confirm whether RPO supplementation could result in similar parasite-specific beneficial effects in other community settings, as well as to explore the underlying mechanisms.
| Item Type: | Article |
|---|---|
| Funders: | RMK-11 (Eleventh Malaysia Plan) Grant PD219/16, Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases (NIAID) |
| Uncontrolled Keywords: | Red palm olein; Soil-transmitted helminth; Reinfection; Vitamin A deficiency; Randomized controlled trial |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RX Homeopathy > Diseases, treatment, etc |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Nov 2024 03:53 |
| Last Modified: | 27 Nov 2024 03:53 |
| URI: | http://eprints.um.edu.my/id/eprint/38377 |
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