Tan, Hun Yee and Wong, Yin How and Kasbollah, Azahari and Md Shah, Mohammad Nazri and Perkins, Alan Christopher and Yeong, Chai Hong (2023) Operational nuclear research reactors in the Asia-Pacific with potential for medical radionuclide production. Nuclear Medicine Communications, 44 (4). pp. 227-243. ISSN 01433636, DOI https://doi.org/10.1097/MNM.0000000000001665.
Full text not available from this repository.Abstract
Personalised cancer treatment is of growing importance and can be achieved via targeted radionuclide therapy. Radionuclides with theranostic properties are proving to be clinically effective and are widely used because diagnostic imaging and therapy can be accomplished using a single formulation that avoids additional procedures and unnecessary radiation burden to the patient. For diagnostic imaging, single photon emission computed tomography (SPECT) or positron emission tomography (PET) is used to obtain functional information noninvasively by detecting the gamma (gamma) rays emitted from the radionuclide. For therapeutics, high linear energy transfer (LET) radiations such as alpha (alpha), beta (beta(-)) or Auger electrons are used to kill cancerous cells in close proximity, whereas sparing the normal tissues surrounding the malignant tumour cells.One of the most important factors that lead to the sustainable development of nuclear medicine is the availability of functional radiopharmaceuticals. Nuclear research reactors play a vital role in the production of medical radionuclides for incorporation into clinical radiopharmaceuticals. The disruption of medical radionuclide supplies in recent years has highlighted the importance of ongoing research reactor operation. This article reviews the current status of operational nuclear research reactors in the Asia-Pacific region that have the potential for medical radionuclide production. It also discusses the different types of nuclear research reactors, their operating power, and the effects of thermal neutron flux in producing desirable radionuclides with high specific activity for clinical applications.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant No: FRGS/1/2019/SKK06/TAYLOR/02/3], Faculty of Health and Medical Sciences, Taylor’s University, Malaysia, Faculty of Health and Medical Sciences, University of Western Australia |
| Uncontrolled Keywords: | Nuclear medicine; Nuclear research reactor; Neutron activation; Radionuclides |
| Subjects: | R Medicine > R Medicine (General) > Medical technology |
| Divisions: | Faculty of Medicine > Biomedical Imaging Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 10 Nov 2024 03:18 |
| Last Modified: | 10 Nov 2024 03:18 |
| URI: | http://eprints.um.edu.my/id/eprint/38375 |
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