Hong, Jesrine Gek Shan and Kumar, Sailesh (2023) Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction. Clinical Science, 137 (8). pp. 579-595. ISSN 0143-5221, DOI https://doi.org/10.1042/CS20220300.
Full text not available from this repository.Abstract
Fetal growth restriction (FGR) leading to low birth weight (LBW) is a major cause of neonatal morbidity and mortality worldwide. Normal placental development involves a series of highly regulated processes involving a multitude of hormones, transcription factors, and cell lin-eages. Failure to achieve this leads to placental dysfunction and related placental diseases such as pre-clampsia and FGR. Early recognition of at-risk pregnancies is important be-cause careful maternal and fetal surveillance can potentially prevent adverse maternal and perinatal outcomes by judicious pregnancy surveillance and careful timing of birth. Given the association between a variety of circulating maternal biomarkers, adverse pregnancy, and perinatal outcomes, screening tests based on these biomarkers, incorporating mater-nal characteristics, fetal biophysical or circulatory variables have been developed. However, their clinical utility has yet to be proven. Of the current biomarkers, placental growth fac-tor and soluble fms-like tyrosine kinase 1 appear to have the most promise for placental dysfunction and predictive utility for FGR.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Circulating biomarkers; Placental dysfunction; Utility; Predicting; Fetal growth restriction |
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicine > Obstetrics & Gynaecology Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Jun 2023 07:07 |
| Last Modified: | 27 Jun 2023 07:07 |
| URI: | http://eprints.um.edu.my/id/eprint/38339 |
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