Fu, Jolene Yin Ling and Pukhari, Muhammad Harith and Bador, Maria Kahar and Sam, I-Ching and Chan, Yoke Fun (2023) Humoral and T Cell immune responses against SARS-CoV-2 after primary and homologous or heterologous booster vaccinations and breakthrough infection: A longitudinal cohort study in Malaysia. Viruses-Basel, 15 (4). ISSN 1999-4915, DOI https://doi.org/10.3390/v15040844.
Full text not available from this repository.Abstract
Vaccine efficacy against SARS-CoV-2 could be compromised by the emergence of SARS-CoV-2 variants and it is important to study how it impacts the booster vaccination regime. We investigated the humoral and T cell responses longitudinally in vaccinated uninfected (n = 25) and post-COVID-19 individuals (n = 8), and those who had received a BNT162b2 booster following complete two-doses regimes of either BNT162b2 (homologous) (n = 14) or ChAdOx1-S (heterologous) (n = 15) vaccines, by means of a SARS-CoV-2 pseudovirus neutralization test and QuantiFERON SARS-CoV-2 assay. Vaccinated post-COVID-19 individuals showed higher neutralizing antibodies with longer durability against SARS-CoV-2 wild type (WT) and Omicron spikes, but demonstrated similar declining T cell responses compared to the uninfected vaccinated. Two doses of BNT162b2 induced higher neutralizing antibodies against WT and T cell responses than ChAdOx1-S for six months. The BNT162b2 booster confers a greater humoral response against WT, but a similar cross-neutralizing antibody against Omicron and T cell responses in the homologous booster group compared to the heterologous booster group. Breakthrough infection in the homologous booster group (n = 11) significantly increased the neutralizing antibody, but T cell responses remained low. Our data may impact government public health policy regarding the administration of mix-and-match vaccines, where both vaccination regimes can be employed should there be shortages of certain vaccines.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia, MG004-2022 |
| Uncontrolled Keywords: | SARS-CoV-2; Omicron; BNT162b2 vaccine; ChAdOx1-S vaccine; Booster; Neutralizing antibody; T cell responses |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Dec 2023 04:44 |
| Last Modified: | 01 Dec 2023 04:44 |
| URI: | http://eprints.um.edu.my/id/eprint/38336 |
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