Chau, Sze Chun and Chong, Pit Shan and Jin, Hongkai and Tsui, Ka Chun and Khairuddin, Sharafuddin and Tse, Anna Chung Kwan and Lew, Sze Yuen and Tipoe, George Lim and Lee, Chi Wai and Fung, Man-Lung and Wong, Kah Hui and Lim, Lee Wei (2023) Hericium erinaceus promotes anti-inflammatory effects and regulation of metabolites in an animal model of cerebellar ataxia. International Journal of Molecular Sciences, 24 (7). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms24076089.
Full text not available from this repository.Abstract
Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although previous study demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), the mechanisms of H.E. treatment on the neuroinflammatory response, neurotransmission, and related metabolites remain largely unknown. We demonstrated that 3-AP rats treated with 25 mg/kg H.E. extracts had improved motor coordination and balance in the accelerated rotarod and rod tests. We showed that the H.E. treatment upregulated the expression of Tgfb1, Tgfb2, and Smad3 genes to levels comparable to those in the non-3-AP control group. Interestingly, we also observed a significant correlation between Tgfb2 gene expression and rod test performance in the 3-AP saline group, but not in the non-3-AP control or H.E.+3-AP groups, indicating a relationship between Tgfb2 gene expression and motor balance in the 3-AP rat model. Additionally, we also found that the H.E. treatment increased mitochondrial COX-IV protein expression and normalized dopamine-serotonin neurotransmission and metabolite levels in the cerebellum of the H.E.+3-AP group compared to the 3-AP saline group. In conclusion, our findings suggest that the H.E. treatment improved motor function in the 3-AP rat model, which was potentially mediated through neuroprotective mechanisms involving TGFB2-Smad3 signaling via normalization of neurotransmission and metabolic pathways.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Hericium erinaceus; Cerebellar ataxia; Incoordination; Brain inflammation; Neuroprotective agents; Neurotransmission |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine Faculty of Medicine > Medicine Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Jul 2024 08:05 |
| Last Modified: | 16 Jul 2024 08:05 |
| URI: | http://eprints.um.edu.my/id/eprint/38331 |
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