Farhan, Nesrain and Al-Maleki, Anis Rageh and Ataei, Shahla and Sarih, Norazilawati Muhamad and Yahya, Rosiyah (2023) Synthesis, DFT study, theoretical and experimental spectroscopy of fatty amides based on extra-virgin olive oil and their antibacterial activity. Bioorganic Chemistry, 135. ISSN 0045-2068, DOI https://doi.org/10.1016/j.bioorg.2023.106511.
Full text not available from this repository.Abstract
Medication products from natural materials are preferred due to their minimal side effects. Extra-virgin olive oil (EVOO) is a highly acclaimed Mediterranean diet and a common source of lipids that lowers morbidity and disease severity. This study synthesised two fatty amides from EVOO: hydroxamic fatty acids (FHA) and fatty hydrazide hydrate (FHH). The Density Functional Theory (DFT) was applied to quantum mechanics computation. Nuclear magnetic resonance (NMR), Fourier transforms infrared (FTIR), and element analysis were used to characterise fatty amides. Likewise, the minimum inhibitory concentration (MIC) and timing kill assay were determined. The results revealed that 82 % for FHA and 80 % for FHH conversion were achieved. The amidation reagent/EVOO ratio (mmol: mmol) was 7:1, using the reaction time of 12 h and hexane as an organic solvent. The results further revealed that fatty amides have high antibacterial activity with low concentration at 0.04 mu g/ mL during eight h of FHA and 0.3 mu g/mL during ten h of FHH. This research inferred that FHA and FHH could provide an alternative and effective therapeutic strategy for bacterial diseases. Current findings could provide the basis for the modernisation/introduction of novel and more effective antibacterial drugs derived from natural products.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education & Scientific Research (MHESR) FP052-2016, Universiti Malaya PG335-2016A |
| Uncontrolled Keywords: | Extra virgin olive oil; Fatty hydroxamic acids; Fatty hydrazide hydrate; Antibacterial activity; Fatty amide |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine Faculty of Science > Department of Chemistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 14 May 2024 01:28 |
| Last Modified: | 14 May 2024 01:28 |
| URI: | http://eprints.um.edu.my/id/eprint/38310 |
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