Mahindran, Elancheleyen and Zaman, Wan Safwani Wan Kamarul and Noordin, Khairul Bariah Ahmad Amin and Tan, Yuen-Fen and Nordin, Fazlina (2023) Mesenchymal stem cell-derived extracellular vesicles: Hype or hope for skeletal muscle anti-frailty. International Journal of Molecular Sciences, 24 (9). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms24097833.
Full text not available from this repository.Abstract
Steadily rising population ageing is a global demographic trend due to the advancement of new treatments and technologies in the medical field. This trend also indicates an increasing prevalence of age-associated diseases, such as loss of muscle mass (sarcopenia), which tends to afflict the older population. The deterioration in muscle function can cause severe disability and seriously affects a patient's quality of life. Currently, there is no treatment to prevent and reverse age-related skeletal muscle ageing frailty. Existing interventions mainly slow down and control the signs and symptoms. Mesenchymal stem cell-derived extracellular vesicle (MSC-EV) therapy is a promising approach to attenuate age-related skeletal muscle ageing frailty. However, more studies, especially large-scale randomised clinical trials need to be done in order to determine the adequacy of MSC-EV therapy in treating age-related skeletal muscle ageing frailty. This review compiles the present knowledge of the causes and changes regarding skeletal muscle ageing frailty and the potential of MSC-EV transplantation as a regenerative therapy for age-related skeletal muscle ageing frailty and its clinical trials.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Kebangsaan Malaysia [GUP-2020-024] |
| Uncontrolled Keywords: | mesenchymal stem cell; extracellular vesicles; ageing; frailty; skeletal muscle |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Engineering > Biomedical Engineering Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 15 Jun 2024 03:10 |
| Last Modified: | 15 Jun 2024 03:10 |
| URI: | http://eprints.um.edu.my/id/eprint/38268 |
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