Chua, K.H.; Chai, H.C.; Puthucheary, S.D. (2008) Identification of Burkholderia pseudomallei Mimotope using Phage display approach. Journal of Applied Sciences, 8 (21). pp. 3999-4003. ISSN 1812-5654
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Abstract
This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of B. pseudomallei site-specific recombinase, which is a phage integrase family protein. Overall, the mimotope obtained in this study could be a potential candidate for the development of a cost effective diagnostic test or vaccine in the future.
| Item Type: | Article |
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| Creators: |
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| Journal or Publication Title: | Journal of Applied Sciences |
| Additional Information: | Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSI |
| Uncontrolled Keywords: | Burkholderia pseudomallei ; melioidosis ; phage display ; mimotope |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 01 Nov 2012 12:22 |
| Last Modified: | 01 Nov 2012 12:22 |
| URI: | http://eprints.um.edu.my/id/eprint/3822 |
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