Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide-(TAA-) induced liver injury in Rats

Wong, W.L.; Abdulla, M.A.; Chua, K.H.; Kuppusamy, U.R.; Tan, Y.S.; Sabaratnam, V. (2012) Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide-(TAA-) induced liver injury in Rats. Evidence-Based Complementary and Alternative Medicine, 2012. ISSN 1741-427X

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    Abstract

    Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5�or�1�g/kg) daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury.

    Item Type: Article
    Creators:
    1. Wong, W.L.
    2. Abdulla, M.A.
    3. Chua, K.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    4. Kuppusamy, U.R.
    5. Tan, Y.S.
    6. Sabaratnam, V.
    Journal or Publication Title: Evidence-Based Complementary and Alternative Medicine
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Molecular Medicine
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms azrahani halim
    Date Deposited: 01 Nov 2012 11:13
    Last Modified: 01 Nov 2012 11:13
    URI: http://eprints.um.edu.my/id/eprint/3818

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