DNA fingerprinting of human isolates of Burkholderia pseudomallei from different geographical regions of Malaysia

Chua, K.H.; See, K.H.; Thong, K. L.; Puthucheary, S.D. (2010) DNA fingerprinting of human isolates of Burkholderia pseudomallei from different geographical regions of Malaysia. Tropical Biomedicine, 27 (3). pp. 517-524. ISSN 0127-5720

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    Abstract

    Melioidosis is an infectious disease caused by Burkholderia pseudomallei and endemic in Southeast Asia. One hundred and forty six clinical isolates of B. pseudomallei from different states in Malaysia were obtained and molecular typing was carried out using pulsed-field gel electrophoresis (PFGE). Overall, nine clusters were successfully identified. Burkholderia pseudomallei isolates used in this study were found to be genetically diverse and there were differences in the clusters of isolates from peninsular and east Malaysia. BS9 cluster was the most common cluster and found in all the states while BS2 cluster only existed in a particular state. Based on the PFGE analysis, the distribution of different B. pseudomallei clinical isolates in Malaysia was mapped.

    Item Type: Article
    Creators:
    1. Chua, K.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. See, K.H.
    3. Thong, K. L.(Institute of Biological Sciences, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    4. Puthucheary, S.D.
    Journal or Publication Title: Tropical Biomedicine
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Molecular Medicine
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms azrahani halim
    Date Deposited: 31 Oct 2012 11:36
    Last Modified: 22 Jan 2014 16:35
    URI: http://eprints.um.edu.my/id/eprint/3807

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