Co-inheritance of variants/mutations in Malaysian patients with Crohn s disease

Chua, K.H.; Ng, C.C.; Hilmi, I.; Goh, K.L. (2012) Co-inheritance of variants/mutations in Malaysian patients with Crohn s disease. Genetics and Molecular Research, 11 (3). pp. 3115-3121.

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    Abstract

    Crohn�s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn�s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn�s disease development. Based on the sequencing results, a homozygous 5�-UTR-59 G to A variant in exon 1 (SNP6) was observed in a patient who carried SNP5, while a heterozygous SNP6 variant was detected in the other patient who carried SNP5. No other associated mutations or polymorphisms were detected in the two patients who carried the JW1 variant of the CARD15/NOD2 gene.

    Item Type: Article
    Creators:
    1. Chua, K.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Ng, C.C.
    3. Hilmi, I.
    4. Goh, K.L.
    Journal or Publication Title: Genetics and Molecular Research
    Uncontrolled Keywords: Crohn's disease; Malaysian; Mutations; Variants
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms azrahani halim
    Date Deposited: 23 Oct 2012 12:13
    Last Modified: 23 Oct 2012 12:13
    URI: http://eprints.um.edu.my/id/eprint/3792

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