Potential uses of human salivary protein and peptide analysis in the diagnosis of disease

Kawas, S.A.; Rahim, Z.H.A.; Ferguson, D.B. (2012) Potential uses of human salivary protein and peptide analysis in the diagnosis of disease. Archives of Oral Biology, 57 (1). pp. 1-9. ISSN 00039969

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    Abstract

    Saliva is an important body fluid containing a complex mixture of proteins, peptides and other substances. These are not only important in maintaining the health of the oral cavity but also may yield information about oral and systemic disease. Comprehensive analysis and identification of the proteomic content of human saliva may contribute to the understanding of oral pathophysiology and provide a foundation for the recognition of potential biomarkers of human disease. The collection of saliva samples is non-invasive, safe, and inexpensive. It seems likely that testing methods can be developed which can be used in general medical or dental practice. However, it is important to realize that the collection of saliva must be carefully controlled. In this paper we review the progress in the analysis of the human salivary proteome and summarise the diagnostic possibilities that have been explored. The precautions in collecting saliva, and some of the factors which would have to be considered if a diagnostic test were to be generally adopted are discussed.

    Item Type: Article
    Creators:
    1. Kawas, S.A.
    2. Rahim, Z.H.A.
    3. Ferguson, D.B.
    Journal or Publication Title: Archives of Oral Biology
    Additional Information: Cited By (since 1996): 3 Export Date: 10 September 2012 Source: Scopus CODEN: AOBIA PubMed ID: 21774913 Language of Original Document: English Correspondence Address: Ferguson, D.B.; Department of Oral Biology, Faculty of Dentistry, Kuala Lumpur, Malaysia; email: dbferguson@supanet.com Chemicals/CAS: Biological Markers; Proteome; Salivary Proteins and Peptides References: Lee, Y.-H., Wong, D.T., Saliva: An emerging biofluid for early detection of diseases (2009) Am J Dent, 22, pp. 241-248; Huang, C.M., Comparative proteomic analysis of human whole saliva (2004) Arch Oral Biol, 49, pp. 951-962; Hu, S., Xie, Y., Ramachandran, P., Loo, R.R.O., Li, Y., Loo, J.A., Wong, D.T., Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry (2005) Proteomics, 5 (6), pp. 1714-1728. , DOI 10.1002/pmic.200401037; Guo, T., Rudnick, P.A., Wang, W., Lee, C.S., Devoe, D.L., Balgley, B.M., Characterization of the human salivary proteome by capillary isoelectric focusing/nanoreversed-phase liquid chromatography coupled with ESI-tandem MS (2006) Journal of Proteome Research, 5 (6), pp. 1469-1478. , DOI 10.1021/pr060065m; Hu, S., Denny, P., Xie, Y., Loo, J.A., Wolinsky, L.E., Li, L., Differentially expressed protein markers in human submandibular and sublingual secretions (2004) Int J Oncol, 25, pp. 1423-1430; Denny, P., Hagen, F.K., Hardt, M., Liao, L., Yan, W., Arellanno, M., The proteomes of human parotid and submandibular/sublingual gland saliva collected as the ductal secretions (2008) J Proteome, 7, pp. 1994-2006; Hu, S., Yu, T., Xie, Y., Yang, Y., Li, Y., Zhou, X., Tsung, S., Wong, D.T., Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry (2007) Cancer Genomics and Proteomics, 4 (2), pp. 55-64; Herr, A.E., Hatch, A.V., Throckmorton, D.J., Tran, H.M., Brennan, J.S., Giannobile, W.V., Singh, A.K., Microfluidic immunoassays as rapid saliva-based clinical diagnostics (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (13), pp. 5268-5273. , DOI 10.1073/pnas.0607254104; Oppenheim, F.G., Salih, E., Siqueira, W.L., Zhang, W., Helmerhorst, E.J., Salivary proteome and its genetic polymorphisms (2007) Annals of the New York Academy of Sciences, 1098, pp. 22-50. , DOI 10.1196/annals.1384.030, Oral-based Diagnostics; Huq, N.L., Cross, K.J., Ung, M., Myroforidis, H., Veith, P.D., Chen, D., Stanton, D., Reynolds, E.C., A review of the salivary proteome and peptidome and saliva-derived peptide therapeutics (2007) International Journal of Peptide Research and Therapeutics, 13 (4), pp. 547-564. , DOI 10.1007/s10989-007-9109-9; Ghafouri, B., Tagesson, C., Lindahl, M., Mapping of proteins in human saliva using two-dimensional gel electrophoresis and peptide mass fingerprinting (2003) Proteomics, 3 (6), pp. 1003-1015. , DOI 10.1002/pmic.200300426; Baldini, C., Giusti, C.L., Bazzichi, L., Lucacchini, A., Bombardieri, S., Proteomic analysis of the saliva. 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    Uncontrolled Keywords: Biomarkers Diagnostic methods Oral disease Proteome analysis Saliva biological marker diagnostic agent proteome saliva protein chemistry human methodology mouth disease pathophysiology physiology proteomics review Biological Markers Humans Mouth Diseases Salivary Proteins and Peptides
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Biology
    Depositing User: Mr Ahmad Azwan Azman
    Date Deposited: 10 Oct 2012 09:54
    Last Modified: 10 Oct 2012 09:54
    URI: http://eprints.um.edu.my/id/eprint/3746

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