Papadimitriou, Nikos and Muller, David and van den Brandt, Piet A. and Geybels, Milan and Patel, Chirag J. and Gunter, Marc J. and Lopez, David S. and Key, Timothy J. and Perez-Cornago, Aurora and Ferrari, Pietro and Vineis, Paolo and Weiderpass, Elisabete and Boeing, Heiner and Agudo, Antonio and Sanchez, Maria-Jose and Overvad, Kim and Kuehn, Tilman and Fortner, Renee T. and Palli, Domenico and Drake, Isabel and Bjartell, Anders and Santiuste, Carmen and Bueno-de-Mesquita, Bas H. and Krogh, Vittorio and Tjonneland, Anne and Lauritzen, Dorthe Furstrand and Gurrea, Aurelio Barricarte and Quiros, Jose Ramon and Stattin, Par and Trichopoulou, Antonia and Martimianaki, Georgia and Karakatsani, Anna and Thysell, Elin and Johansson, Ingegerd and Ricceri, Fulvio and Tumino, Rosario and Larranaga, Nerea and Khaw, Kay Tee and Riboli, Elio and Tzoulaki, Ioanna and Tsilidis, Konstantinos K. (2020) A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study. European Journal of Nutrition, 59 (7). pp. 2929-2937. ISSN 1436-6207, DOI https://doi.org/10.1007/s00394-019-02132-z.
Full text not available from this repository.Abstract
Purpose The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.
| Item Type: | Article |
|---|---|
| Funders: | World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme (WCRF 2014/1180), International Agency for Research on Cancer, Deutsche Krebshilfe, German Cancer Research Center (DKFZ) (Germany), Federal Ministry of Education & Research (BMBF), Deutsche Krebshilfe, Federal Ministry of Education & Research (BMBF) |
| Uncontrolled Keywords: | Diet; Nutrition; Epidemiology; Cohort study; Prostate cancer |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 09 Mar 2023 06:45 |
| Last Modified: | 09 Mar 2023 06:45 |
| URI: | http://eprints.um.edu.my/id/eprint/37237 |
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