Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers

Chong, Y.M.; Tan, J.; Zubaidah, Z.; Rahimah, A.; Kuldip, K.; George, E. (2006) Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers. Med J Malaysia, 61 (2). pp. 217-220.

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    Abstract

    Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia. An individual can co-inherit both the alpha and beta thalassaemia genes. This study determined the frequency of cincurrent carriers of alpha thalassaemia in 231 beta thalassaemia carriers. Gap-PCR was done on extracted DNA of the beta thalassaemia samples to check for alpha thalassaemia 1 molecular defect. Eight (3.5) samples were found to have concurrently inherited the alpha thalassaemia 1 deletion. The significant carrier rare for alpha thalassaemia 1 indicates the need for the implementation of DNA analysis to complement thalassaemia screening in high risk populations.

    Item Type: Article
    Creators:
    1. Chong, Y.M.
    2. Tan, J.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    3. Zubaidah, Z.
    4. Rahimah, A.
    5. Kuldip, K.
    6. George, E.
    Journal or Publication Title: Med J Malaysia
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Thalassaemia, Concurrent carries, screening, gene interaction
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 04 Oct 2012 10:14
    Last Modified: 04 Oct 2012 10:14
    URI: http://eprints.um.edu.my/id/eprint/3716

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