Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers

Chong, Y.M.; Tan, J.; Zubaidah, Z.; Rahimah, A.; Kuldip, K.; George, E. (2006) Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers. Med J Malaysia, 61 (2). pp. 217-220.

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    Abstract

    Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia. An individual can co-inherit both the alpha and beta thalassaemia genes. This study determined the frequency of cincurrent carriers of alpha thalassaemia in 231 beta thalassaemia carriers. Gap-PCR was done on extracted DNA of the beta thalassaemia samples to check for alpha thalassaemia 1 molecular defect. Eight (3.5) samples were found to have concurrently inherited the alpha thalassaemia 1 deletion. The significant carrier rare for alpha thalassaemia 1 indicates the need for the implementation of DNA analysis to complement thalassaemia screening in high risk populations.

    Item Type: Article
    Journal or Publication Title: Med J Malaysia
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Thalassaemia, Concurrent carries, screening, gene interaction
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 04 Oct 2012 10:14
    Last Modified: 04 Oct 2012 10:14
    URI: http://eprints.um.edu.my/id/eprint/3716

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