Chong, Y.M.; Tan, J.; Zubaidah, Z.; Rahimah, A.; Kuldip, K.; George, E. (2006) Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers. Med J Malaysia, 61 (2). pp. 217-220.
Abstract
Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia. An individual can co-inherit both the alpha and beta thalassaemia genes. This study determined the frequency of cincurrent carriers of alpha thalassaemia in 231 beta thalassaemia carriers. Gap-PCR was done on extracted DNA of the beta thalassaemia samples to check for alpha thalassaemia 1 molecular defect. Eight (3.5) samples were found to have concurrently inherited the alpha thalassaemia 1 deletion. The significant carrier rare for alpha thalassaemia 1 indicates the need for the implementation of DNA analysis to complement thalassaemia screening in high risk populations.
| Item Type: | Article |
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| Creators: | - Chong, Y.M.
- Tan, J.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
- Zubaidah, Z.
- Rahimah, A.
- Kuldip, K.
- George, E.
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| Journal or Publication Title: | Med J Malaysia |
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| Additional Information: | Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
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| Uncontrolled Keywords: | Thalassaemia, Concurrent carries, screening, gene interaction |
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| Subjects: | R Medicine |
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| Divisions: | Faculty of Medicine |
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| Depositing User: | Ms Haslinda Lahuddin |
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| Date Deposited: | 04 Oct 2012 10:14 |
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| Last Modified: | 04 Oct 2012 10:14 |
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| URI: | http://eprints.um.edu.my/id/eprint/3716 |
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