Mousavi, Seyyed Mojtaba and Low, Foo Wah and Hashemi, Seyyed Alireza and Lai, Chin Wei and Ghasemi, Younes and Soroshnia, Sadaf and Savardashtaki, Amir and Babapoor, Aziz and Pynadathu Rumjit, Nelson and Goh, Su Mei and Amin, Nowshad and Tiong, Sieh Kiong (2020) Development of graphene based nanocomposites towards medical and biological applications. Artificial Cells Nanomedicine and Biotechnology, 48 (1). pp. 1189-1205. ISSN 2169-1401, DOI https://doi.org/10.1080/21691401.2020.1817052.
Full text not available from this repository.Abstract
Graphene and its derivative materials present high potential towards medical and biological applications, including drug delivery and bioimaging, due to their exceptional properties such as thermal conductivity and high specific surface area. The main focus of this work is to review the current development of graphene materials and the derivatives for biocompatible, bioimaging and drug delivery applications. Also, the synthesis methods with variation of graphene nanocomposites and the functionalisation will be further explained. For the graphene approaches, chemical vapour deposition (CVD) is the best-known technique to make high-quality graphene sheet by growth route with mass production. By considering the organic graphene nanocomposites, the biocompatibility and cytotoxic effects against graphene nanocomposites were evaluated for biomedical employments such as high quality bioimaging and effective drug delivery for cancer treatments. For example, graphene oxide incorporated with PEG and loaded with SN 38 for camptothecin analolgue as anticancer drug and revealed high cytotoxicity has an effect of 1000 times better effect than CPT in HCT-116 cells. Their drug delivery ability for bothin-vivoandin-vitroapplications compared to the controlled drugs such as doxorubicin (DOX) will be discussed accordingly. The graphene and its deriavatives possess some intriguing properties, which will lead to drug delivery due to strong biocompatibility and cyctotoxic effect towards biomedicine applications.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Tenaga Nasional Sdn. Bhd., Malaysia (10436494/B/2019008), Universiti Tenaga Nasional Sdn. Bhd., Malaysia (10436494/B/2019097), Universiti Tenaga Nasional Sdn. Bhd., Malaysia ( RJO10517919/iRMC/Publication), Global Collaborative Programme SATU Joint Research Scheme (ST012-2019), Impact-Oriented Interdisciplinary Research Grant from University of Malaya (IIRG018A-2019) |
| Uncontrolled Keywords: | Graphene; Medical; Biological; Cancer therapy; Doxorubicin |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 30 May 2023 01:43 |
| Last Modified: | 30 May 2023 01:43 |
| URI: | http://eprints.um.edu.my/id/eprint/37115 |
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