High prevalence of Alpha- and Beta-Thalassemia in the Kadazandusuns in east Malaysia: challenges in providing effective health care for an indigenous group

Tan, J.; Lee, P.C.; Wee, Y.C.; Tan, K.L.; Mahali, N.F.; George, E.; Chua, K.H. (2010) High prevalence of Alpha- and Beta-Thalassemia in the Kadazandusuns in east Malaysia: challenges in providing effective health care for an indigenous group. Journal of Biomedicine and Biotechnology, 2010. ISSN 1110-7243

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    Abstract

    Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia. alpha-and beta-thalassemia were confirmed in 33.6 and 12.8, of the individuals studied respectively. The high prevalence of alpha- and beta-thalassemia in the Kadazandusuns indicates that thalassemia screening, genetic counseling, and prenatal diagnosis should be included as part of their healthcare system. This preliminary paper serves as a baseline for further investigations into the health and genetic defects of the major indigenous population in Sabah, East Malaysia.

    Item Type: Article
    Creators:
    1. Tan, J.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Lee, P.C.
    3. Wee, Y.C.
    4. Tan, K.L.
    5. Mahali, N.F.
    6. George, E.
    7. Chua, K.H.
    Journal or Publication Title: Journal of Biomedicine and Biotechnology
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Comorbidity; Humans; Malaysia/epidemiology
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 02 Oct 2012 10:14
    Last Modified: 02 Oct 2012 10:14
    URI: http://eprints.um.edu.my/id/eprint/3708

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