Fung, Shin Yee and Tan, N.H. and Liew, S.H. and Sim, S.M. and Aguiyi, J.C. (2009) The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats. Tropical Biomedicine, 26 (1). pp. 80-84. ISSN 0127-5720,
|
PDF
The_protective_effects_of_Mucuna_pruriens_seed_extract_against_histopathological_changes_induced_by_Malayan_cobra_(Naja_sputatrix)_venom.pdf - Published Version Download (4MB) |
Abstract
Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages.
Item Type: | Article |
---|---|
Funders: | UNSPECIFIED |
Additional Information: | 1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50602 Kuala Lumpur, Malaysia. |
Uncontrolled Keywords: | Molecular Medicine; Mucuna pruriens (Velvet beans) |
Subjects: | R Medicine |
Divisions: | Faculty of Medicine |
Depositing User: | Fung Shin Yee |
Date Deposited: | 27 Sep 2012 03:09 |
Last Modified: | 13 Jul 2020 07:55 |
URI: | http://eprints.um.edu.my/id/eprint/3699 |
Actions (login required)
View Item |