Aglago, Elom K. and Huybrechts, Inge and Murphy, Neil and Casagrande, Corinne and Nicolas, Genevieve and Pischon, Tobias and Fedirko, Veronika and Severi, Gianluca and Boutron-Ruault, Marie-Christine and Fournier, Agnes and Katzke, Verena and Kuehn, Tilman and Olsen, Anja and Tjonneland, Anne and Dahm, Christina C. and Overvad, Kim and Lasheras, Cristina and Agudo, Antonio and Sanchez, Maria-Jose and Amiano, Pilar and Maria Huerta, Jose and Ardanaz, Eva and Perez-Cornago, Aurora and Trichopoulou, Antonia and Karakatsani, Anna and Martimianaki, Georgia and Palli, Domenico and Pala, Valeria and Tumino, Rosario and Naccarati, Alessio and Panico, Salvatore and Bueno-de-Mesquita, Bas and May, Anne and Derksen, Jeroen W. G. and Hellstrand, Sophie and Ohlsson, Bodil and Wennberg, Maria and Van Guelpen, Bethany and Skeie, Guri and Brustad, Magritt and Weiderpass, Elisabete and Cross, Amanda J. and Ward, Heather and Riboli, Elio and Norat, Teresa and Chajes, Veronique and Gunter, Marc J. (2020) Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort. Clinical Gastroenterology and Hepatology, 18 (3). 654+. ISSN 1542-3565, DOI https://doi.org/10.1016/j.cgh.2019.06.031.
Full text not available from this repository.Abstract
BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. RESULTS: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; P-trend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; P-trend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; P-trend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; P-trend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; P-trend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (P-heterogeneity = .026). CONCLUSIONS: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.
| Item Type: | Article |
|---|---|
| Funders: | AIRE-ONLUS, ISCIII RETIC [Grant No: RD06/0020], Nordic Center of Excellence Programme on Food, Nutrition and Health, Swedish Scientific Council , and Regional Government of Skåne |
| Uncontrolled Keywords: | Epidemiologic; Seafood; Omega 3; Tumorigenesis |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 06 Nov 2024 01:45 |
| Last Modified: | 06 Nov 2024 01:48 |
| URI: | http://eprints.um.edu.my/id/eprint/36826 |
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