Suk, Vicit Rizal Eh and Mohd Latif, Farhanim and Teo, Yin Yin and Misran, Misni (2020) Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30. Journal of Food Science and Technology-Mysore, 57 (9). pp. 3259-3266. ISSN 0022-1155, DOI https://doi.org/10.1007/s13197-020-04357-x.
Full text not available from this repository.Abstract
Lipid nanocarrier displays the advantages over conventional drug carriers as they are formulated with biodegradable and non-irritant lipids. However, the main drawbacks are the agglomeration of lipid particles, instability over storage, low drug loading, and the burst release of active ingredients. In this study, we investigated the effects of various polysorbate nonionic surfactants namely Tween 20, 40, 60, or 80 on the nanostructured lipid carrier (NLC). NLC incorporated with polysorbate nonionic surfactant was prepared by using high-pressure homogenization technique. The average size was reduced to 139.9 +/- 15.8 nm in the presence of Tween 80 and remained stable in nano-size even incubated for 28 days. Encapsulation of l-ascorbic acid or Gold Tri.E 30 showed a high encapsulation efficiency of more than 75%, where the highest was Gold Tri.E in the presence of Tween 60 at 99.7%. In vitro release study showed that the release of both l-ascorbic acid and Gold Tri.E was significantly reduced in NLC with Tween as compared to bare active ingredients and NLC without Tween. In conclusion, the incorporation of Tween successfully produced a lipid nanocarrier that has the potential to be developed as a carrier of various active ingredients such as nutrients, extracts, and drugs.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Centre of Innovation & Commercialization (UMCIC), University of Malaya through Geran Prototaip [RU005U-2016], Prototype Research Grant Scheme (PRGS) [PR002-2018A], Fundamental Research Grant [GPF065B-2018], Sime Darby Plantation Sdn. Bhd., Malaysia |
| Uncontrolled Keywords: | Nanostructured lipid carrier; Polysorbate nonionic surfactant; TWEEN; Vitamin; In-vitro release |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 04 Oct 2023 07:29 |
| Last Modified: | 04 Oct 2023 07:29 |
| URI: | http://eprints.um.edu.my/id/eprint/36809 |
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