Arumugam, Bavani and Palanisamy, Uma Devi and Chua, Kek Heng and Kuppusamy, Umah Rani (2020) Amelioration of hyperglycemia-induced oxidative damage in ARPE-19 cells by myricetin derivatives isolated from Syzygium malaccense. Journal of Functional Foods, 67. ISSN 1756-4646, DOI https://doi.org/10.1016/j.jff.2020.103844.
Full text not available from this repository.Abstract
Myricetin derivatives (F2) isolated from leaf extract of Syzygium malaccense (Malay apple) which contains myricitrin predominantly, could potentially serve as functional food ingredient based on previous findings. The present study aimed to investigate the protective effects of F2 against hyperglycemia-induced oxidative stress in ARPE-19 (retinal pigment epithelium) cells; a diabetic retinopathy (DR) model. F2 showed effective inhibition of advanced glycation end products (AGE) formation. The derivatives attenuated high glucose (30 mM)-induced stress condition in ARPE-19 cells by reducing intracellular reactive oxygen species (ROS). At transcriptional level, F2 activated Nrf2 pathway besides upregulating antioxidant enzymes and other protective factors. In addition, protective effect of F2 against formation of AGE correlated with its ability to downregulate gene expression of inflammatory factor, NFkB1 and receptor for AGE. The findings showed that F2 was effective in preventing oxidative damage-induced by high glucose in ARPE-19 and could be developed as an adjuvant to manage DR.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antiglycation; Diabetic retinopathy; Hyperglycemia; Myricitrin; Oxidative stress; Syzygium malaccense |
| Subjects: | R Medicine R Medicine > R Medicine (General) > Medical technology |
| Divisions: | Faculty of Medicine Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Feb 2024 02:02 |
| Last Modified: | 16 Feb 2024 02:02 |
| URI: | http://eprints.um.edu.my/id/eprint/36775 |
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