Koh, V. C. A. and Pauls, J. P. and Wu, E. L. and Stevens, M. C. and Ho, Y. K. and Lovell, N. H. and Lim, E. (2020) A centralized multi-objective model predictive control for a biventricular assist device: An in vitro evaluation. Biomedical Signal Processing and Control, 59. ISSN 1746-8094, DOI https://doi.org/10.1016/j.bspc.2020.101914.
Full text not available from this repository.Abstract
Control of a biventricular assist device (BiVAD) is more challenging than control of a left ventricular assist device due to the process interactions between control loops in a multi-input-multi-output system. Hence, a single centralized multi-objective model predictive controller (CMO-MPC) has been developed to control a BiVAD. The CMO-MPC aims to: 1) adapt pump flow rate according to the Frank-Starling mechanism, 2) avoid ventricular suction, and 3) avoid vascular congestion. The CMO-MPC was benchmarked against a constant-speed (CS) setting in exercise, postural change, and systemic vascular resistance change tests in a mock circulation loop. The CMO-MPC increased pump flow rate from 5.0 L/min to 7.6 L/min in the exercise scenario, which was higher than the pump flow rate in the CS setting (6.0 L/min). In the postural change test, right ventricular end diastolic pressure (RVEDP) decreased to a minimum at 0.1 mmHg and 2.0 mmHg in the CS setting and the CMO-MPC, respectively, indicating that the CMO-MPC could minimize the risk of ventricular suction (with higher minimum RVEDP than the CS setting) when there was a sudden decrease in venous return. In all tests, the CMO-MPC could adapt pump flow rate without resulting events of ventricular suction and vascular congestion. (C) 2020 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | National Health and Medical Research Council Centre for Research Excellence in Advanced Cardio-respiratory Therapies Improving OrgaN Support (ACTIONS) [Grant No: APP1079421] |
| Uncontrolled Keywords: | Frank-Starling mechanism; Mock circulation loop; Physiological control; Ventricular suction; Vascular congestion |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) > Medical technology |
| Divisions: | Faculty of Engineering > Biomedical Engineering Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 05 Nov 2024 08:21 |
| Last Modified: | 05 Nov 2024 08:21 |
| URI: | http://eprints.um.edu.my/id/eprint/36725 |
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