Al-Douri, Y. and Gherab, K. and Batoo, Khalid Mujasam and Raslan, Emad H. (2020) Detecting the DNA of dengue serotype 2 using aluminium nanoparticle doped zinc oxide nanostructure: Synthesis, analysis and characterization. Journal of Materials Research and Technology-JMR&T, 9 (3). pp. 5515-5523. ISSN 2238-7854, DOI https://doi.org/10.1016/j.jmrt.2020.03.076.
Full text not available from this repository.Abstract
Biosensor devices hold great potential for various applications in detecting disease and monitoring disease progression. Electrochemical biosensors represent an important subclass of chemical sensors, they are extremely inexpensive, rapid and sensitive. Aluminium nanoparticle doped zinc oxide nanostructure based integrated electrochemical biosensor has been designed and developed for the dengue virus's diagnosis. By utilizing a hard mask and thermal evaporator systems (PVD), interdigitated electrode (IDE) is designed with Ag (silver) and integrated on Si-AZO. The platform of fabricated (IDE(Ag)/AZO/Si) is functionalized involving DNA immobilization, hybridization and surface modification to set up electrical detection for DNA probe specific to dengue in concentrations, 100 fM, 100 pM, 10 nM and DNA probe. The sensitivity of wide ranged detected achieved is 55.54 mu A nM(-1) cm(-2), as well as for limit detection, 15.46 mu A nM(-1) and limit quantification, 51.53 mu A nM(-1). Also, it is extracted, 0.0604 mu A nM(-1), the linear regression 0.8563 and the standard deviation of current is 0.34 mu A. Our biosensors device is fast and highly effective; thus, it may potentially assist future advances in the diagnosis of dengue viruses. (C) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC -ND license (http://creativecommondorg/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [Grant No: RU001-2018], Deanship of Scientific Research, King Saud University [Grant No: RG-1437-030] |
| Uncontrolled Keywords: | Interdigitated electrodes; Immobilization; DNA probe; Electrical properties |
| Subjects: | T Technology > TJ Mechanical engineering and machinery T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 04 Nov 2024 08:09 |
| Last Modified: | 04 Nov 2024 08:09 |
| URI: | http://eprints.um.edu.my/id/eprint/36706 |
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