Lim, Jasmine and Amantakul, Akara and Shariff, Nisha and Lojanapiwat, Bannakij and Alip, Adlinda and Ong, Teng Aik and Thevarajah, Shankaran and Ahmayuddin, Firdaus and Mathew, Adeline and Sriplakich, Supon and Vuthiwong, Jaraspong and Chong, Flora Li Tze and Saad, Marniza (2020) Clinical outcomes of abiraterone acetate and predictors of its treatment duration in metastatic castration-resistant prostate cancer: Real-world experience in the Southeast Asian cohort. Cancer Medicine, 9 (13). pp. 4613-4621. ISSN 2045-7634, DOI https://doi.org/10.1002/cam4.3101.
Full text not available from this repository.Abstract
It is of much interest to understand the efficacy of abiraterone acetate (AA) in routine clinical practice. We assessed the clinical outcome of AA in patients with metastatic castration-resistant prostate cancer (mCRPC) and determined clinical factors associated with AA treatment duration in real-world setting. This real-world cohort consisted of 93 patients with mCRPC treated with AA in Thailand (58.1%) and Malaysia (41.9%). Primary endpoints were overall survival (OS) and biochemical progression-free survival (bPFS). Secondary endpoints were predictors associated with AA treatment duration evaluated with Cox proportional hazards regression. Around 74% were chemotherapy-naive. The median AA treatment duration was 10 months (IQR 5.6-17.1). Malaysians had a relatively lower median OS and bPFS (OS 17.8 months; 95% CI 6.4-29.1, bPFS 10.4 months; 95% CI 8.8-12.0) compared to Thais (OS 27.0 months; 95% CI 11.3-42.7, bPFS 14.0 months; 95% CI 5.8-22.2), although it did not achieve statistical significance (P > .05). Patients with longer AA treatment duration (>10 months) had lower risk of death and longer bPFS, compared to those with shorter AA treatment duration (<= 10 months) (hazard ratio HR] 0.10, 95% CI 0.05-0.22 and HR 0.13, 95% CI 0.06-0.25, respectively). Multivariable analysis showed that PSA at AA initiation, presence of PSA response and chemotherapy-naive were independently associated with AA duration (P < .05). Abiraterone acetate is well-tolerated in the Southeast Asian cohort with comparable survival benefits to other Asian populations in real-world setting. Lower PSA levels at AA initiation, presence of PSA response, and chemotherapy-naive were significant in determining AA treatment duration.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Chemotherapy; Malaysia; Overall survival; Progression-free survival; PSA response; Thailand |
| Subjects: | R Medicine > RD Surgery |
| Divisions: | Faculty of Medicine > Surgery Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 04 Nov 2024 04:55 |
| Last Modified: | 04 Nov 2024 04:55 |
| URI: | http://eprints.um.edu.my/id/eprint/36695 |
Actions (login required)
 |
View Item |
