Lee, Hwai Jien and Pok, Lydia Say Lee and Ng, Choung Min and Yahya, Fariz and Sockalingam, Sargunan and Tee, Ying Chew and Raja, Jasmin (2020) Fatigue and associated factors in a multi-ethnic cohort of rheumatoid arthritis patients. International Journal of Rheumatic Diseases, 23 (8). pp. 1088-1093. ISSN 1756-1841, DOI https://doi.org/10.1111/1756-185X.13897.
Full text not available from this repository.Abstract
Introduction Fatigue is an important yet infrequently evaluated component in patients with rheumatoid arthritis (RA) and may have a major impact on quality of life. Objectives To evaluate fatigue, identify factors associated with fatigue and assess the effect of fatigue on health-related quality of life (HRQoL) in a multi-ethnic cohort of RA patients. Methods A cross-sectional study was performed in patients who fulfilled European League Against Rheumatism/ American College of Rheumatology 2010 criteria for RA. Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) questionnaire was used to assess fatigue. Potential factors for fatigue were categorized into RA-related (gender, seropositivity rheumatoid factor and/or anti-citrullinated protein antibody], disease duration, visual analog scale pain score, Disease Activity Score of 28 joints - erythrocyte sedimentation rate DAS28-ESR], ESR, hemoglobin level, functional disability Health Assessment Questionnaire - Disability Index, HAQ-DI score], EQ-5D-3L, concomitant prednisolone use and number of conventional synthetic disease-modifying anti-rheumatic drugs csDMARDs] used) and non-RA-related (age, body mass index, ethnicity and number of co-morbidities). Results A total of 214 patients (86.9% female) were included; the median age was 62 (25-91) years and 67.3% were seropositive. Seventy-six (33.5%) patients had moderate disease activity, 12 (5.6%) had high disease activity and 152 (71%) patients had mild difficulties to moderate disability HAQ-DI scores. Median of total FACIT-F score was 113.2 (36.3-160.0). Joint factors of younger age, longer disease duration, higher HAQ score (increased functional disability), and lower EQ-5D (poorer HRQoL) were significantly associated with higher levels of fatigue (allP < .02). Conclusion Fatigue was associated with functional disability and has a significant impact on HRQoL in RA. Fatigue assessment should be considered in routine clinical practice for RA patients.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Disease activity; FACIT score; Fatigue; Functional disability; HRQoL; Rheumatoid arthritis |
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Science > Institute of Mathematical Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 14 Nov 2023 02:33 |
| Last Modified: | 03 Dec 2023 02:10 |
| URI: | http://eprints.um.edu.my/id/eprint/36600 |
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