Abd-Aziz, Noraini and Kamaruzman, Nur Izyani and Poh, Chit Laa (2020) Development of MicroRNAs as potential therapeutics against cancer. Journal of Oncology, 2020. ISSN 16878450, DOI https://doi.org/10.1155/2020/8029721.
Full text not available from this repository.Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials.
| Item Type: | Article |
|---|---|
| Funders: | Centre for Virus and Vaccine Research, Sunway University Research Centre |
| Uncontrolled Keywords: | Cancer gene therapy; Carcinogenesis; Clinical trial (topic); Gene control; Gene function; Gene targeting; Human; Malignant neoplasm; Molecular evolution |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Oct 2024 08:02 |
| Last Modified: | 29 Oct 2024 08:02 |
| URI: | http://eprints.um.edu.my/id/eprint/36543 |
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