The effect of systemic ibuprofen on gingival inflammation in humans

Taiyeb Ali, T.B.; Waite, I.M. (1993) The effect of systemic ibuprofen on gingival inflammation in humans. Journal of Clinical Periodontology, 20 (10). pp. 723-728. ISSN 0303-6979

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    Abstract: This clinical trial investigated the influence of short-term ibuprofen therapy on the early phase of the treatment of adult chronic periodontitis. The subjects were 17 patients in good general health referred for specialist periodontal treatment, having moderate chronic adult periodontitis. A series of assessments were made every 2 weeks over an 8-week period, including evaluations of oral hygiene, gingival inflammation and probing pocket depths. All participants received oral hygiene instruction, and following baseline examinations, had half the dentition, chosen at random, treated by scaling and root planing. The patients were randomly distributed into 2 groups, a test group receiving a 14-day course of 800 mg ibuprofen daily, in 4 divided doses, and a control group who did not receive any drug regime. At the 2-week assessment following the drug regime, significantly greater reduction in gingival bleeding, colour and pocketing was detected in the test compared with the control group. The beneficial effects were less evident thereafter. Although clinical application of the regime used in this study would not be justified by these results, further research into anti-inflammatory agents as an adjunct in the treatment of periodontal diseases could be considered, in the light of the beneficial effect on gingivitis in the early phase of periodontal treatment reported.

    Item Type: Article
    1. Taiyeb Ali, T.B.
    2. Waite, I.M.
    Journal or Publication Title: Journal of Clinical Periodontology
    Additional Information: Cited By (since 1996): 10 Export Date: 26 August 2012 Source: Scopus CODEN: JCPED PubMed ID: 8276982 Language of Original Document: English Correspondence Address: Taiyeb Ali, T.B.; Dental Faculty, University of Malaya, 59100 Kuala Lumpur, Malaysia Chemicals/CAS: Ibuprofen, 15687-27-1 Tradenames: brufen
    Uncontrolled Keywords: Ibuprofen non-steroidal anti-inflammatory agents treatment of chronic periodontitis nonsteroid antiinflammatory agent adult article clinical article controlled study drug efficacy female human male mouth hygiene oral drug administration periodontitis Chronic Disease Dental Prophylaxis Gingivitis Root Planing
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Mr Ahmad Azwan Azman
    Date Deposited: 04 Sep 2012 14:21
    Last Modified: 04 Sep 2012 14:21

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