Low, Yan Jie and Andriyana, Andri and Ang, Bee Chin and Zainal Abidin, Nor Ishida (2020) Bioresorbable and degradable behaviors of PGA: Current state and future prospects. POLYMER ENGINEERING AND SCIENCE, 60 (11). pp. 2657-2675. ISSN 00323888, DOI https://doi.org/10.1002/pen.25508.
Full text not available from this repository.Abstract
Polyglycolic acid (PGA) is a class of semicrystalline, bioresorbable polymers that have been widely used in a number of applications. No other bioresorbable materials can fully replace PGA in tissue engineering. Understanding degradation mechanisms in PGA is important for improving the efficiency and effectiveness in various fields including implantation. This review begins with a discussion on terminology of polymer degradation and hydrolytic degradation mechanism with a delineative model. This review also focus on previous degradation studies taking advantage of its fast-degrading behavior and the mechanism behind hexafluoroisopropanol (HFIP) being the sole solvent for PGA. Finally, the merits of PGA are discussed with many potential future applications along with their associated challenges.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia (Grant No. FP047‐2019A), Universiti Malaya (Grant No. FG010-17AFR, RP041A-17AET, RP041C-17AET) |
| Uncontrolled Keywords: | bioresorbable polymer; degradation mechanism; hydrolytic degradation; polyglycolic acid; solubility in HFIP; tissue engineering |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering > Department of Chemical Engineering |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Dec 2023 07:03 |
| Last Modified: | 29 Dec 2023 07:03 |
| URI: | http://eprints.um.edu.my/id/eprint/36403 |
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