Lett, J. Anita and Sagadevan, Suresh and Paiman, Suriati and Mohammad, Faruq and Schirhagl, Romana and Leonard, Estelle and Alshahateet, Solhe F. and Oh, Won-Chun (2020) Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants. Journal of Materials Research and Technology-JMR&T, 9 (6). pp. 12824-12833. ISSN 2238-7854, DOI https://doi.org/10.1016/j.jmrt.2020.09.037.
Full text not available from this repository.Abstract
Polylactic acid (PLA), although has many interesting physicochemical characteristics, the strong hydrophobicity and a lack of antibacterial activity restricting its widespread application in the medical sector. In a view of addressing some of the limitations of PLA, the current study aimed to test the antibacterial efficacy of active metal-doped bioceramic/PLA composite formed by the fused deposition manufacturing (FDM) technique. For the testing, we prepared polyvinyl alcohol (PVA) bound silver-hydroxyapatite (Ag-HAp) composite and further applied as a low-temperature coating onto the PLA scaffold designed for the appropriate cell development, differentiation, and bio-mineral establishment. From the analysis, we revealed that the larger surface area of three-dimensional (3D) printed composite material having the matrix porosity makes it a perfect biocompatible material with no loss to its mechanical potency. The HAp/PLA and Ag-HAp/PLA composites were tested for the hemocompatibility, and antibacterial activity (gram-positive and gram-negative bacteria). Further, the mechanical property of the Ag-HAp/PLA scaffold was tested. The results demonstrated that the Ag-HAp/PLA composite offers the biocompatibility and antibacterial ability and therefore can serve as the potential bone implant material. (C) 2020 The Author(s). Published by Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Polylactic acid scaffolds; Silver doped hydroxyapatite; Fused deposition method; Antibacterial studies; Hemocompatibility; Hardness study |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Nov 2023 13:16 |
| Last Modified: | 29 Nov 2023 13:16 |
| URI: | http://eprints.um.edu.my/id/eprint/36298 |
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