Kamarudin, Yasmin and Skeats, Matthew K. and Ireland, Anthony J. and Barbour, Michele E. (2020) Chlorhexidine hexametaphosphate as a coating for elastomeric ligatures with sustained antimicrobial properties: A laboratory study. American Journal of Orthodontics and Dentofacial Orthopedics, 158 (5). E73-E82. ISSN 0889-5406, DOI https://doi.org/10.1016/j.ajodo.2020.07.027.
Full text not available from this repository.Abstract
Introduction: White spot lesions are a common side effect of orthodontic treatment. This laboratory study aimed to explore the suitability of chlorhexidine hexametaphosphate (CHX-HMP) as a coating for orthodontic elastomeric ligatures to provide sustained chlorhexidine (CHX) release. Methods: Dissolution kinetics of CHX-HMP were firstly explored using spectroscopy and a colorimetric phosphate assay. Elastomeric ligatures were categorized into 3 groups-acetone-conditioned, ethanol-conditioned, and as received-and were then immersed in 5 mM CHX-HMP suspension or 5 mM chlorhexidine digluconate solution and rinsed. CHX release was measured over 8 weeks, and the effects of conditioning and immersion on elastomeric force and extension at rupture and surface topography were investigated. Results: CHX-HMP exhibited a gradual equilibration that had not reached equilibrium within 8 weeks, releasing soluble CHX and a mixture of polyphosphate and orthophosphate. CHX digluconate-treated ligatures showed no CHX release, whereas CHX-HMP-treated ligatures showed varying degrees of release. As received, CHX-HMP-treated ligatures showed a modest release of CHX up to 7 days. Acetone conditioning did not enhance CHX-HMP uptake or subsequent CHX release and caused a deterioration in mechanical properties. Ethanol conditioning enhanced CHX-HMP uptake (63) and led to a sustained CHX release over 8 weeks without affecting mechanical properties. Conclusions: Within the inherent limitations of this in-vitro study, CHX-HMP led to a sustained release of CHX from orthodontic elastomeric ligatures after ethanol conditioning. Conditioned and coated elastomeric ligatures may ultimately find application in the prevention of white spot lesions in orthodontic patients.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Anti-Bacterial agents; Anti-Infective agents; Chlorhexidine; Humans; Phosphates |
| Subjects: | R Medicine R Medicine > RK Dentistry R Medicine > RK Dentistry > Oral surgery |
| Divisions: | Faculty of Dentistry Faculty of Dentistry > Dept of Children’s Dentistry And Orthodontics |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Nov 2023 12:50 |
| Last Modified: | 29 Nov 2023 12:50 |
| URI: | http://eprints.um.edu.my/id/eprint/36293 |
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