Azmi, Mohamad Nurul and Sian, Tan Aik and Suhaimi, Munirah and Kamarudin, Muhamad Noor Alfarizal and Din, Mohd Fadzli Md. and Nafiah, Mohd Azlan and Thomas, Noel F. and Kadir, Habsah Abdul and Awang, Khalijah (2021) Synthesis of indolostilbenes via FeCl3-promoted oxidative cyclisation and their biological effects on NG108-15 cell viability and H2O2-induced cytotoxicity. Journal of Physical Science, 32 (1). pp. 69-89. ISSN 1675-3402, DOI https://doi.org/10.21315/jps2021.32.1.6.
Full text not available from this repository.Abstract
A convenient and simple radical cation cyclisation of 3,5-dimethoxystilbene was developed using the commercially available FeCl3under mild condition. It enabled the construction of a new class of indolostilbenes (i.e., indole-stilbene hybrid). Various parameters were investigated to obtain better yields (more than 42) compared with the previously reported. The synthesised indolostilbenes were characterised, and their mechanism of formation was discussed. The synthesised compounds were submitted for biological assay on NG108-15 cell viability and H2O2-induced cytotoxicity. The result showed that two indolostilbenes have promising protective activity against H2O2. © Penerbit Universiti Sains Malaysia, 2021. This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).
| Item Type: | Article |
|---|---|
| Funders: | MyPair PHC Hibiscus[203.PKIMIA. 6782002], Universiti Sains Malaysia Fellowship Scheme |
| Uncontrolled Keywords: | Indolostilbene;FeCl3 oxidative coupling;Pericyclic reaction;H2O2 protective properties;Cyclisation |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 28 Oct 2022 02:32 |
| Last Modified: | 28 Oct 2022 02:32 |
| URI: | http://eprints.um.edu.my/id/eprint/35995 |
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