Pandarathodiyil, Anitha Krishnan and Ramanathan, Anand and Garg, Ranjana and Doss, Jennifer Geraldine and Abd Rahman, Fazliny and Wan Abdul Ghani, Wan Maria Nabillah and Warnakulasuriya, Saman (2021) Lactate dehydrogenase levels in the saliva of cigarette and e-cigarette smokers (vapers): A comparative analysis. Asian Pacific Journal of Cancer Prevention, 22 (10). pp. 3227-3235. ISSN 15137368, DOI https://doi.org/10.31557/APJCP.2021.22.10.3227.
Full text not available from this repository.Abstract
Background: We examined the lactate dehydrogenase (LDH) enzyme levels in the saliva of vapers (e-cigarette users) and compared the data with cigarette smokers and a control group of non-smokers and non-vapers. Methods: Subjects were recruited among those responding to a social media announcement or patients attending the SEGi Oral Health Care Centre between May and December 2019, and among some staff at the centre. Five ml of unstimulated whole saliva was collected and salivary LDH enzyme activity levels were measured with a LDH colorimetric assay kit. Salivary LDH activity level was determined for each group and compared statistically. Results: Eighty-eight subjects were categorized into three groups (control n=30, smokers n=29, and vapers n=29). The mean ± standard deviation (SD) values for salivary LDH activity levels for vapers, smokers, and control groups were 35.15 ± 24.34 mU/ml, 30.82 ± 20.73 mU/ml, and 21.45 ± 15.30 mU/ml, respectively. The salivary LDH activity levels of smoker and vaper groups were significantly higher than in the control group (p = 0.031; 0.017). There was no significant difference of salivary LDH activity level in vapers when compared with smokers (p= 0.234). Conclusion: Our findings showed higher LDH levels in the saliva of vapers when compared with controls, confirming cytotoxic and harmful effects of e-cigarettes on the oral mucosa. © 2021. All Rights Reserved.
| Item Type: | Article |
|---|---|
| Funders: | SEGi Internal Research Fund [Grant No.: SEGiIRF/2018-4/FoD-14/79] |
| Uncontrolled Keywords: | E-cigarettes; Enzyme; LDH; Saliva; Smokers; Vapers |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Nov 2023 08:02 |
| Last Modified: | 27 Nov 2023 08:02 |
| URI: | http://eprints.um.edu.my/id/eprint/35788 |
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