In vitro susceptibilities of Malaysian clinical isolates of Cryptococcus neoformans var. grubii and Cryptococcus gattii to five antifungal drugs

Tay, S.T.; Tanty Haryanty, T.; Ng, K.P.; Rohani, M.Y.; Hamimah, H. (2006) In vitro susceptibilities of Malaysian clinical isolates of Cryptococcus neoformans var. grubii and Cryptococcus gattii to five antifungal drugs. Mycoses, 49 (4). pp. 324-330. ISSN 1439-0507

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Abstract

The in vitro susceptibilities of Malaysian clinical isolates of Cryptococcus neoformans var. grubii and C . gattii to five antifungal drugs (amphotericin B, flucytosine, fluconazole, itraconazole and ketoconazole) were determined using the Etest method. None of the Malaysian isolates was resistant to amphotericin B and ketoconazole. Isolates resistant to flucytosine, fluconazole and itraconazole were observed in this study. Minimum inhibition concentrations (MICs) of > or = 32 microg ml(-1) against flucytosine, > or = 64 microg ml(-1) against fluconazole and > or = 1 microg ml(-1) against itraconazole were noted in four (8.3), two (4.2) and one (2.1) isolates respectively. There was no significant difference in the MICs for both Cryptococcus species (P > 0.05), indicating that C. gattii was as susceptible as var. grubii to all the antifungal drugs tested. No significant difference in the MICs for both Cryptococcus species collected from 1980 to 1990 and 2002 to 2004 were observed (P > 0.05).

Item Type: Article
Creators:
  1. Tay, S.T.
  2. Tanty Haryanty, T.
  3. Ng, K.P.
  4. Rohani, M.Y.
  5. Hamimah, H.(Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
Journal or Publication Title: Mycoses
Additional Information: Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Cryptococcus neoformans;C. gattii;antifungal drugs;Etest method
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: hamimah hamimah hassan
Date Deposited: 06 Aug 2012 09:38
Last Modified: 06 Aug 2012 09:38
URI: http://eprints.um.edu.my/id/eprint/3555

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