Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures

Tay, Sun Tee and Abidin, Ira Azzura Zainal and Hassan, Hamimah and Ng, Kee Peng (2011) Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures. Medical Mycology, 49 (5). pp. 556-560. ISSN 1369-3786, DOI https://doi.org/10.3109/13693786.2010.551424.

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Official URL: https://doi.org/10.3109/13693786.2010.551424

Abstract

This study was conducted to determine the proteinase, phospholipase, and biofilm forming abilities of Candida isolates in blood cultures of specimens from patients at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Proteinase and phospholipase activities were detected in 93.7% and 73.3%, respectively, of 15 Candida albicans isolates. Amongst the 26 non-C. albicans Candida isolates, proteinase and phospholipase activities were detected in 88.5% and 7.7% of the isolates, respectively. There was no significant difference in the expression levels of proteinase amongst the Candida isolates studied (P = 0.272), but the phospholipase activity of C. albicans was significantly higher than that of the non-C. albicans Candida isolates (P = 0.003). There was no significant difference in the biofilm forming abilities of C. albicans and non-C. albicans Candida isolates on the polystyrene microtiter wells (P = 0.379). In addition, the findings of this study demonstrate increased resistance of Candida isolates in biofilms to amphotericin and fluconazole, as compared to their planktonic counterparts.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Proteinase; phospholipase; biofilm; antifungal susceptibility; Candida
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: hamimah hamimah hassan
Date Deposited: 06 Aug 2012 01:16
Last Modified: 18 Nov 2019 08:01
URI: http://eprints.um.edu.my/id/eprint/3549

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