Sa'adon, Shafizah and Ansari, Mohamed Nainar Mohamed and Abd Razak, Saiful Izwan and Yusof, Abdul Halim Mohd and Faudzi, Ahmad Athif Mohd and Sagadevan, Suresh and Nayan, Nadirul Hasraf Mat and Anand, Joseph Sahaya and Amin, Khairul Anuar Mat (2021) Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies. Pharmaceutics, 13 (11). ISSN 1999-4923, DOI https://doi.org/10.3390/pharmaceutics13111900.
Full text not available from this repository.Abstract
Transdermal drug delivery systems (TDDS) have drawn more interest from pharmaceutical scientists because they could provide steady blood levels and prevent the first-pass metabolism over a longer period. Polyvinyl alcohol (PVA) has been widely used in this application due to its biocompatibility, non-toxicity, nanofiber and hydrogel-forming ability. Despite those benefits, their morphology would easily be destroyed by continuous water absorption and contribute to burst drug release due to its hydrophilicity. The aim of this study was to prepare the diclofenac sodium (DS)-medicated dual layer PVA patch using a combination of electrospinning and cryogelation (freeze-thaw) methods to improve the physicochemical properties and drug compatibility and investigate the release of the DS-medicated dual layer PVA patch. Morphological observations using scanning electron microscopy (SEM) verified the polymer-polymer interaction between both layers, whereas Fourier transform infrared (FTIR) spectroscopy has demonstrated the compatibility of DS in PVA matrix up to 2% w/v of PVA volume. The DS loads were found amorphously distributed efficaciously in PVA matrix as no visible spectra of DS-PVA interaction were detected. The DS-medicated dual layer PVA patch with a thicker nanofiber layer (3-milliliter running volume), three freeze-thaw cycles and 2% DS loading labeled as 2%DL(B)3C show the lowest swelling capacity (18.47%). The in vitro assessment using Franz diffusion cells showed that the 2%DL(B)3C indicates a better sustained release of DS, with 53.26% of the DS being released after 12 h. The 2%DL(B)3C owned a flux (J(ss)) of 0.256 mg/cm(2)/h and a permeability coefficient (K-p) value of 0.020 cm/h. Thus, the results demonstrate that DS-medicated dual layer PVA patches prepared via a combination of electrospinning and cryogelation are capable of releasing drugs for up to 24 h and can serve as a drug reservoir in the skin, thereby extending the pharmacologic effects of DS.
| Item Type: | Article |
|---|---|
| Funders: | Innovative & Research Management Centre (iRMC), Universiti Tenaga Nasional, Malaysia, research publication BOLD grant[J510050002], Universiti Teknologi Malaysia[04G51] |
| Uncontrolled Keywords: | Electrospinning;Nanofibers;Cryogelation;Diclofenac sodium;Polyvinyl alcohol;Dual layer;Transdermal drug delivery;In vitro release;Franz diffusion |
| Subjects: | R Medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 14 Oct 2022 05:05 |
| Last Modified: | 14 Oct 2022 05:05 |
| URI: | http://eprints.um.edu.my/id/eprint/35323 |
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