Khir, Nur Adila Fatin Mohd and Razak, Mohd Ridzuan Mohd Abdul and Nordin, Fariza Juliana and Sofyan, Nur Rahimah Fitrah Mohd and Rajab, Nur Fadilah and Sarip, Rozie (2021) Synthesis, antiproliferative and antimalarial activities of dinuclear silver(I) complexes with triphenylphosphine and rhiosemicarbazones ligands. Indonesian Journal of Chemistry, 21 (3). pp. 575-587. ISSN 1411-9420, DOI https://doi.org/10.22146/ijc.57343.
Full text not available from this repository.Abstract
A series of six sulfur-bridged Binuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using various techniques such as elemental analysis, Fourier-transform infrared (FTIR) spectroscopy, as well as H-1, C-13, P-31{H-1}s, COSY, and H-1-C-13 nuclear magnetic resonance (NMR) spectroscopy, it was found that the thiosemicarbazone ligand exists in the form of a thione rather than thiol tautomer. Subsequently, MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell lines, were used to investigate the in vitro antiproliferative activities of these complexes. In all cases, the IC50 values were in the potent micromolar range. Besides, the aforementioned complexes also had good antiplasmodial activity against chloroquine-resistant P. falciparum, as per the results of histidine-rich protein 2 (HRP2) assays and cytotoxicity evaluations of MDBK cells.
| Item Type: | Article |
|---|---|
| Funders: | Geran Penyelidikan Universiti Malaya (UMRG) -AFR Frontier Science [RG357-15AFR] FR, University of Malaya IPPP Grant[PG002-2015A] |
| Uncontrolled Keywords: | Thiosemicarbazone;Silver complexes;Antiplasmodial;Antiproliferative;Phosphine |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 17 Sep 2022 09:43 |
| Last Modified: | 17 Sep 2022 09:43 |
| URI: | http://eprints.um.edu.my/id/eprint/35117 |
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