Runcharoen, Chakkaphan and Fukunaga, Koya and Sensorn, Insee and Iemwimangsa, Nareenart and Klumsathian, Sommon and Tong, Hang and Vo, Nam Sy and Le, Ly and Hlaing, Tin Maung and Thant, Myo and Mohd Zain, Shamsul and Mohamed, Zahurin and Pung, Yuh-Fen and Capule, Francis and Nevado, Jose and Silao, Catherine Lynn and Al-Mahayri, Zeina N. and Ali, Bassam R. and Yuliwulandari, Rika and Prayuni, Kinasih and Zahroh, Hilyatuz and Noor, Dzul Azri Mohamed and Xangsayarath, Phonepadith and Xayavong, Dalouny and Kounnavong, Sengchanh and Sayasone, Somphou and Kordou, Zoe and Liopetas, Ioannis and Tsikrika, Athina and Tsermpini, Evangelia-Eirini and Koromina, Maria and Mitropoulou, Christina and Patrinos, George P. and Kesornsit, Aumpika and Charoenyingwattana, Angkana and Wattanapokayakit, Sukanya and Mahasirimongkol, Surakameth and Mushiroda, Taisei and Chantratita, Wasun (2021) Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Human Genome Variation, 8 (1). ISSN 2054-345X, DOI https://doi.org/10.1038/s41439-021-00135-z.
Full text not available from this repository.Abstract
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.
| Item Type: | Article |
|---|---|
| Funders: | Thailand Center of Excellence for Life Sciences (TCELS), International Research Network [IRN60W0003], Thailand Research Fund (TRF), UAEU, Ministry of Education [31R091] |
| Uncontrolled Keywords: | Pharmacogenomics; Drug efficacy; Next-generation sequencing; Southeast Asian; Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 09 Sep 2022 00:20 |
| Last Modified: | 09 Sep 2022 00:20 |
| URI: | http://eprints.um.edu.my/id/eprint/35066 |
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