Fauzi, Muhammad Al Rizqi Dharma and Hendradi, Esti and Pudjiastuti, Pratiwi and Widodo, Riyanto Teguh (2021) Analysis of dissolution of salicylamide from carrageenan based hard-shell capsules: A study of the drug-matrix interaction. Indonesian Journal of Chemistry, 21 (1). pp. 148-156. ISSN 1411-9420, DOI https://doi.org/10.22146/ijc.55047.
Full text not available from this repository.Abstract
In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the drug. Therefore, there is an urgent need to conduct research related to the study of drug-matrix interaction. This paper reports the preparation of a drug delivery system (DDS) in the form of hard-shell capsules containing salicylamide (SCA) and analyses its drug-matrix interaction via dissolution test at different pH media and various release kinetics models. The matrix of hard-shell capsules was prepared from K-carrageenan (CRG), crosslinked with maltodextrin (MD), and plasticized by sorbitol (SOR). The chemical properties of SCA were compared with paracetamol (PCT) using computational analysis to help to depict its drug-matrix interaction. The statistical analyses showed that SCA and PCT at pH 1.2, 4.5, and 6.8 had all different release profiles. Based on the goodness of fit evaluation, the diffusion mechanism of SCA at pH 1.2 and 4.5 could be best described by the Peppas-Sahlin model while the zeroth-order model fitted the dissolution profile at pH 6.8. In summary, it was proven that a different drug-matrix interaction produced a different dissolution profile.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education of Indonesia through the PMDSU (Program Menuju Doktor untuk Sarjana Unggul) scholarship program |
| Uncontrolled Keywords: | Polymer; Carrageenan; Drug release; Release kinetic; Dissolution |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 May 2022 02:02 |
| Last Modified: | 27 May 2022 02:02 |
| URI: | http://eprints.um.edu.my/id/eprint/34859 |
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