Pisani, Luigi and Algera, Anna Geke and Serpa Neto, Ary and Ahsan, Areef and Beane, Abigail and Chittawatanarat, Kaweesak and Faiz, Abul and Haniffa, Rashan and Hashemian, Seyed MohammadReza and Hashmi, Madiha and Imad, Hisham Ahmed and Indraratna, Kanishka and Iyer, Shivakumar and Kayastha, Gyan and Krishna, Bhuvana and Ling, Tai Li and Moosa, Hassan and Nadjm, Behzad and Pattnaik, Rajyabardhan and Sampath, Sriram and Thwaites, Louise and Tun, Ni Ni and Yunos, Nor'azim Mohd and Grasso, Salvatore and Paulus, Frederique and de Abreu, Marcelo Gama and Pelosi, Paolo and Day, Nick and White, Nicholas J. and Dondorp, Arjen M. and Schultz, Marcus J. and Investigators, PRoVENT-iMiC and MORU, . and Network, PROVE (2021) Epidemiological characteristics, ventilator management, and clinical outcome in patients receiving invasive ventilation in intensive care units from 10 Asian middle-incomeCountries (PRoVENT-iMiC): An International, Multicenter, Prospective Study. American Journal of Tropical Medicine and Hygiene, 104 (3). pp. 1022-1033. ISSN 0002-9637, DOI https://doi.org/10.4269/ajtmh.20-1177.
Full text not available from this repository.Abstract
Epidemiology, ventilator management, and outcome in patients receiving invasive ventilation in intensive care units (ICUs) in middle-income countries are largely unknown. PRactice of VENTilation in Middle-income Countries is an international multicenter 4-week observational study of invasively ventilated adult patients in 54 ICUs from 10 Asian countries conducted in 2017/18. Study outcomes included major ventilator settings (including tidal volume VT] and positive end-expiratory pressure PEEP]); the proportion of patients at risk for acute respiratory distress syndrome (ARDS), according to the lung injury prediction score (LIPS), or with ARDS; the incidence of pulmonary complications; and ICU mortality. In 1,315 patients included, median V-T was similar in patients with LIPS < 4 and patients with LIPS >= 4, but lower in patients with ARDS (7.90 6.8-8.9], 8.0 6.8-9.2], and 7.0 5.8-8.4] mL/kg Predicted body weight; P = 0.0001). Median PEEP was similar in patients with LIPS < 4 and LIPS >= 4, but higher in patients withARDS(five 5-7], five 5-8], and 10 5-12] cmH(2)O; P < 0.0001). The proportions of patients with LIPS (3) 4 or with ARDS were 68% (95% CI: 66-71) and 7%(95% CI: 6-8), respectively. Pulmonary complications increased stepwise from patients with LIPS < 4 to patients with LIPS >= 4 and patients with ARDS (19%, 21%, and 38% respectively; P = 0.0002), with a similar trend in ICU mortality (17%, 34%, and 45% respectively; P < 0.0001). The capacity of the LIPS to predict development of ARDS was poor (receiver operating characteristic ROC] area under the curve AUC] of 0.62, 95% CI: 0.54-0.70). In Asian middle-income countries, where two-thirds of ventilated patients are at risk for ARDS according to the LIPS and pulmonary complications are frequent, setting of V-T is globally in line with current recommendations.
| Item Type: | Article |
|---|---|
| Funders: | Wellcome Trust [107367/Z/15/Z], [089276/B/09/7] |
| Uncontrolled Keywords: | Public, Environmental & occupational HealthTropical medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Anaesthesiology Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 21 Jul 2022 04:02 |
| Last Modified: | 21 Jul 2022 04:02 |
| URI: | http://eprints.um.edu.my/id/eprint/34706 |
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