Efficace, Fabio and Iurlo, Alessandra and Patriarca, Andrea and Stagno, Fabio and Bee, Ping-Chong and Ector, Genevieve and Capodanno, Isabella and Elena, Chiara and Bonifacio, Massimiliano and Blijlevens, Nicole M. A. and Caocci, Giovanni and Wan, Chonghua and Abruzzese, Elisabetta and Breccia, Massimo and Cottone, Francesco and Okumura, Iris and Oerlemans, Simone and Cascavilla, Nicola and Albano, Francesco and Kota, Vamsi and Sztankay, Monika and Miggiano, Maria Cristina and Saussele, Susanne and Di Renzo, Nicola and Sora, Federica and Castagnetti, Fausto and Baccarani, Michele and Vignetti, Marco and Rosti, Gianantonio (2021) Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia. Leukemia & Lymphoma, 62 (3). pp. 669-678. ISSN 1042-8194, DOI https://doi.org/10.1080/10428194.2020.1838509.
Full text not available from this repository.Abstract
Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors (TKIs), may enhance quality of research in this area. We performed an international study including 782 CML patients to assess the validity of the EORTC QLQ-CML 24 questionnaire, and to generate HRQOL reference values to facilitate interpretation of results in future studies. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.66 to 0.83. In the confirmatory factor analysis, all standardized factor loadings exceeded the threshold of 0.40 (range 0.49-0.97), confirming the hypothesized scale structure. Reference values stratified by age and sex were also generated. Our findings support the use of the EORTC QLQ-CML 24, in conjunction with the EORTC QLQ-C30, as a valuable measure to assess HRQOL in CML patients.
| Item Type: | Article |
|---|---|
| Funders: | EORTC Quality of Life Group[004/2015] |
| Uncontrolled Keywords: | Quality of life;Tyrosine kinase inhibitors;Symptoms;Chronic myeloid leukemia;Patient-reported outcomes |
| Subjects: | R Medicine R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RD Surgery |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 19 Sep 2022 03:08 |
| Last Modified: | 19 Sep 2022 03:08 |
| URI: | http://eprints.um.edu.my/id/eprint/34690 |
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