Ponvel, Pavapriya and Shahar, Suzana and Singh, Devinder Kaur Ajit and Ludin, Arimi Fitri Mat and Rajikan, Roslee and Rajab, Nor Fadilah and Ai-Vyrn, Chin and Din, Normah Che and Ibrahim, Norhayati and Subramaniam, Ponnusamy and Haron, Hasnah and Ismail, Aniza and Sharif, Razinah and Ramasamy, Kalavathy and Majeed, Abu Bakar Abdul and Ali, Nazlena Mohamad and Mohamad, Mazlyfarina and Noah, Shahrul Azman Mohd and Ibrahim, Azianah Mohd and Safien, Aisyah Mohd and Khalid, Norhayati Mustafa and Fadzil, Nurul Hidayah Md and Mangialasche, Francesca and Kivipelto, Miia (2021) Multidomain intervention for reversal of cognitive frailty, towards a personalized approach (ageless trial): Study design. Journal of Alzheimers Disease, 82 (2). pp. 673-687. ISSN 1387-2877, DOI https://doi.org/10.3233/JAD-201607.
Full text not available from this repository.Abstract
Cognitive frailty (CF) is identified as one of the main precursors of dementia. Multidomain intervention has been found to delay or prevent the onset of CF. Objective: The aim of our present study is to determine the effectiveness of a comprehensive, multidomain intervention on CF; to evaluate its cost effectiveness and the factors influencing adherence toward this intensive intervention. Methods: A total of 1,000 community dwelling older adults, aged 60 years and above will be screened for CF. This randomized controlled trial involves recruitment of 330 older adults with CF from urban, semi-urban, and rural areas in Malaysia. Multidomain intervention comprised of physical, nutritional, cognitive, and psychosocial aspects will be provided to participants in the experimental group (n = 165). The control group (n = 165) will continue their usual care with their physician. Primary outcomes include CF status, physical function, psychosocial and nutritional status as well as cognitive performance. Vascular health and gut microbiome will be assessed using blood and stool samples. A 24-month intensive intervention will be prescribed to the participants and its sustainability will be assessed for the following 12 months. The effective intervention strategies will be integrated as a personalized telerehabilitation package for the reversal of CF for future use. Results: The multidomain intervention developed from this trial is expected to be cost effective compared to usual care as well as able is to reverse CF. Conclusion: This project will be part of the World-Wide FINGERS (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) Network, of which common identifiable data will be shared and harmonized among the consortia.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia[LRGS/1/2019/UM-UKM/1/4] |
| Uncontrolled Keywords: | Cognitive frailty;Multidomain intervention;Older adults; Randomized control trial;Reversal |
| Subjects: | R Medicine R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 15 Sep 2022 06:24 |
| Last Modified: | 15 Sep 2022 06:24 |
| URI: | http://eprints.um.edu.my/id/eprint/34649 |
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