Evidence based guidelines. Diagnosis and management of Guillain-Barre syndrome in ten steps

Leonhard, Sonja E. and Mandarakas, Melissa R. and Aquino Gondim, Francisco De Assis and Bateman, Kathleen and Brito Ferreira, Maria L. and Cornblath, David R. and Van Doorn, Pieter A. and Dourado, Mario E. and Hughes, Richard A. C. and Islam, Badrul and Kusunoki, Susumu and Pardo, Carlos A. and Reisin, Ricardo and Sejvar, James J. and Shahrizaila, Nortina and Soares, Cristiane and Umapathi, Thirugnanam and Wang, Yuzhong and Yiu, Eppie M. and Willison, Hugh J. and Jacobs, Bart C. (2021) Evidence based guidelines. Diagnosis and management of Guillain-Barre syndrome in ten steps. Medicina-Buenos Aires, 81 (5). pp. 817-836. ISSN 0025-7680,

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Abstract

Guillain-Barre syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and in 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diagnostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Guillain-Barre syndrome;Diagnosis;Management;Guideline;Zika virus;Ascending paralysis
Subjects: R Medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 31 May 2022 07:14
Last Modified: 31 May 2022 07:14
URI: http://eprints.um.edu.my/id/eprint/34629

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