Eslam, Mohammed and Alkhouri, Naim and Vajro, Pietro and Baumann, Ulrich and Weiss, Ram and Socha, Piotr and Marcus, Claude and Lee, Way Seah and Kelly, Deirdre and Porta, Gilda and El-Guindi, Mohamed A. and Alisi, Anna and Mann, Jake P. and Mouane, Nezha and Baur, Louise A. and Dhawan, Anil and George, Jacob (2021) Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement. Lancet Gastroenterology & Hepatology, 6 (10). pp. 864-873. ISSN 2468-1253, DOI https://doi.org/10.1016/S2468-1253(21)00183-7.
Full text not available from this repository.Abstract
The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for both adults and children. The definition is most problematic for children, for whom alcohol consumption is usually not a concern. This problematic definition has prompted a consensus to rename and redefine adult NAFLD associated with metabolic dysregulation to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Similarities, distinctions, and differences exist in the causes, natural history, and prognosis of fatty liver diseases in children compared with adults. In this Viewpoint we, an international panel, propose an overarching framework for paediatric fatty liver diseases and an age-appropriate MAFLD definition based on sex and age percentiles. The framework recognises the possibility of other coexisting systemic fatty liver diseases in children. The new MAFLD diagnostic criteria provide paediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, and they align with a definition that is valid across the lifespan.
| Item Type: | Article |
|---|---|
| Funders: | National Health and Medical Research Council of Australia [APP1149976], National Health and Medical Research Council of Australia [APP1107178], National Health and Medical Research Council of Australia [APP2001692], National Health and Medical Research Council of Australia [APP1108422] |
| Uncontrolled Keywords: | Childhood Obesityinsulin-Resistancenonalcoholic Steatohepatitisneck Circumferenceposition Statementhepatic Steatosisgenetic-Variantsnational-Healthincreased Riskunited-States |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine > Paediatrics Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 31 May 2022 06:36 |
| Last Modified: | 31 May 2022 06:36 |
| URI: | http://eprints.um.edu.my/id/eprint/34599 |
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