Iman, Ismail Nurul and Yusof, Nurul Aiman Mohd and Talib, Ummi Nasrah and Ahmad, Nur Aimi Zawami and Norazit, Anwar and Kumar, Jaya and Mehat, Muhammad Zulfadli and Jayabalan, Nanthini and Muthuraju, Sangu and Stefaniuk, Marzena and Kaczmarek, Leszek and Muzaimi, Mustapha (2021) The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder. Frontiers In Behavioral Neuroscience, 15. ISSN 1662-5153, DOI https://doi.org/10.3389/fnbeh.2021.683780.
Full text not available from this repository.Abstract
The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Sains Malaysia [304/PPSP/6315252] [1001/PPSP/8012300], Universiti Kebangsaan Malaysia (UKM) Dana Fundamental [FF-2019-098], National Science Centre, Poland [2019/35/B/NZ4/04077] |
| Uncontrolled Keywords: | IntelliCage system; substance use disorder (SUD); addiction; rodent model; behavior; home cage |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Biomedical Imaging Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Jun 2022 04:41 |
| Last Modified: | 01 Jun 2022 04:41 |
| URI: | http://eprints.um.edu.my/id/eprint/34521 |
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