Interaction of artocarpus lectins with human-iga does not involve asparagine-linked oligosaccharide of the immunoglobulin

Hashim, O.H.; Kobayashi, K.; Taniguchi, N. (1992) Interaction of artocarpus lectins with human-iga does not involve asparagine-linked oligosaccharide of the immunoglobulin. Biochemistry International, 27 (3). pp. 423-429. ISSN 0158-5231

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Abstract

In view of the controversy with respect to the interaction of jacalin with human IgA2, a study was undertaken to assess the reactivity of the Artocarpus heterophyllus lectin, as well as the lectin from Artocarpus integer (lectin C), with subclasses of human immunoglobulin A by ELISA. Our data is consistent with the view that Artocarpus lectins have no affinity for the IgA2 immunoglobulins. In further support of the findings, we have established that N-linked oligosaccharide moieties of IgA have no significant bearing in the lectin-immunoglobulin binding. Interaction was also not affected in the presence of 1 (w/v) BSA.

Item Type: Article
Creators:
  1. Hashim, O.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  2. Kobayashi, K.
  3. Taniguchi, N.
Journal or Publication Title: Biochemistry International
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Molecular Medicine; Human IgA2
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 09:53
Last Modified: 11 Jul 2012 09:53
URI: http://eprints.um.edu.my/id/eprint/3452

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