Comparative analyses of IGA1 binding lectins from seeds of 6 distinct clones of artocarpus-integer

Hashim, Onn Haji and Gendeh, G.S. and Jaafar, M.I.N. (1993) Comparative analyses of IGA1 binding lectins from seeds of 6 distinct clones of artocarpus-integer. Biochemistry and Molecular Biology International, 29 (1). pp. 69-76. ISSN 1039-9712

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Abstract

Purified lectins from seeds of six distinct clones of Artocarpus integer (lectin C) were shown to be structurally and functionally similar. All lectins comprised of two types of non-covalently-linked subunits with apparent M(r) of 13,300 and 16,000. The lectins appeared to interact with several human serum proteins, with the predominance of the IgA1 and C1 inhibitor molecules. Interaction was not detected with IgA2, IgD, IgG and IgM. The lectin Cs were also shown to precipitate monkey, sheep, rabbit, cat, hamster, rat and guinea-pig serum. Due to their uniform properties, lectin C may provide better alternative to the Artocarpus heterophyllus lectin, jacalin, for use in future investigations.

Item Type: Article
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Molecular Medicine; IGA1 Binding Lectins
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 01:51
Last Modified: 24 Oct 2019 08:16
URI: http://eprints.um.edu.my/id/eprint/3451

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