Hashim, O.H.; Gendeh, G.S.; Cheong, C.N.; Jaafar, M.I.N. (1994) Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement. Immunological Investigations, 23 (2). pp. 153-160. ISSN 0882-0139
Full text not available from this repository. (Request a copy)Abstract
The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement.
| Item Type: | Article |
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| Creators: |
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| Journal or Publication Title: | Immunological Investigations |
| Additional Information: | Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | Molecular Medicine; Artocarpus-integer Lectin |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Haslinda Lahuddin |
| Date Deposited: | 11 Jul 2012 09:42 |
| Last Modified: | 11 Jul 2012 09:42 |
| URI: | http://eprints.um.edu.my/id/eprint/3449 |
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