Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement

Hashim, O.H.; Gendeh, G.S.; Cheong, C.N.; Jaafar, M.I.N. (1994) Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement. Immunological Investigations, 23 (2). pp. 153-160. ISSN 0882-0139

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Abstract

The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement.

Item Type: Article
Creators:
  1. Hashim, O.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  2. Gendeh, G.S.
  3. Cheong, C.N.
  4. Jaafar, M.I.N.
Journal or Publication Title: Immunological Investigations
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Molecular Medicine; Artocarpus-integer Lectin
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 09:42
Last Modified: 11 Jul 2012 09:42
URI: http://eprints.um.edu.my/id/eprint/3449

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